Tuesday, 1 July 2014

Cannabis Indica exposing the research

"1973: "Cannabidiol and Cannabis sativa extract protect mice and rats against convulsive agents." http://www.ncbi.nlm.nih.gov/pubmed/4148442
1975: "The anticonvulsant activity of cannabinoids in seizure sensitive gerbils."http://www.ncbi.nlm.nih.gov/pubmed/1178662
"Anticonvulsant activity of four oxygenated cannabidiol derivatives."
http://www.ncbi.nlm.nih.gov/pubmed/1188178
1977: "...CBD is an effective anticonvulsant with a specificity more comparable to drugs clinically effective in major than minor seizures."http://www.ncbi.nlm.nih.gov/pubmed/850145
"Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits...Cannabidiol was effective in blocking convulsions when given concurrently with, but not prior to delta9THC."http://www.ncbi.nlm.nih.gov/pubmed/841172
1978: "Toward drugs derived from cannabis...Cannabidiol is being tried in the clinic against epilepsy and as a hypnotic."http://www.ncbi.nlm.nih.gov/pubmed/351429
1979: "The influence of cannabidiol and delta 9-tetrahydrocannabinol on cobalt epilepsy in rats...evidence that CBD exerts anticonvulsant activity..."http://www.ncbi.nlm.nih.gov/pubmed/113206
"An electrophysiological analysis of the anticonvulsant action of cannabidiol on limbic seizures in conscious rats...support the suggestion that CBD has therapeutic potential as an antiepileptic."http://www.ncbi.nlm.nih.gov/pubmed/477630
1980: "Chronic administration of cannabidiol to healthy volunteers and epileptic patients...All patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected... 4 of the 8 CBD subjects remained almost free of convulsive crises throughout the experiment and 3 other patients demonstrated partial improvement in their clinical condition. CBD was ineffective in 1 patient..."http://www.ncbi.nlm.nih.gov/pubmed/7413719
1981: "The cannabinoids as potential antiepileptics...anticonvulsant properties of the cannabinoids...The anticonvulsant nature of cannabidiol suggests that it has a therapeutic potential in at least three of the four major types of epilepsy: grand mal, cortical focal, and complex partial seizures." http://www.ncbi.nlm.nih.gov/pubmed/6975285
"Antiepileptic potential of cannabidiol analogs."http://www.ncbi.nlm.nih.gov/pubmed/7298873
"Hypnotic and antiepileptic effects of cannabidiol...Seven out of the eight epileptics receiving cannabidiol had improvement of their disease state..."
http://www.ncbi.nlm.nih.gov/pubmed/7028792
1982: "Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice... effects of CBD suggest that the cannabinoid acts to inhibit seizure spread..."http://www.ncbi.nlm.nih.gov/pubmed/6129147
1986: "Anticonvulsant effect of cannabidiol."
http://www.ncbi.nlm.nih.gov/pubmed/3941934
1987: "Structure-anticonvulsant activity relationships of cannabidiol analogs...Cannabidiol (CBD) exhibits anticonvulsant activity in experimental animals and in man."http://www.ncbi.nlm.nih.gov/pubmed/3125480
2001:"Alcohol and marijuana: effects on epilepsy and use by patients with epilepsy...Alcohol abuse can...cause symptoms that mimic seizures...research on the effects of marijuana on seizure activity are inconclusive...evidence suggests that marijuana and its active cannabinoids have antiepileptic effects...studies suggest that cannabidiol may have antiepileptic effects in humans."http://www.ncbi.nlm.nih.gov/pubmed/11737161
2007: "Potential therapeutical effects of cannabidiol in children with pharmacoresistant epilepsy."http://www.ncbi.nlm.nih.gov/pubmed/17112679
2010: "Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. Plant-derived cannabinoids (phytocannabinoids)...studies suggested that cannabidiol (CBD) has anticonvulsant properties..These findings suggest that CBD acts to inhibit epileptiform activity in vitro and seizure severity in vivo. Thus, we demonstrate the potential of CBD as a novel antiepileptic drug in the unmet clinical need associated with generalized seizures." http://www.ncbi.nlm.nih.gov/pubmed/19906779
2012: "Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures...Cannabis sativa... These results extend the anti-convulsant profile of CBD; when combined with a reported absence of psychoactive effects, this evidence strongly supports CBD as a therapeutic candidate for a diverse range of human epilepsies."http://www.ncbi.nlm.nih.gov/pubmed/22520455
2013: "... anticonvulsant effect of cannabidiol... results of the present study showed a protective effect of cannabidiol in both models of seizure..."http://www.ncbi.nlm.nih.gov/pubmed/23644464
"Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy... parents are using cannabidiol-enriched cannabis as a treatment for their children with treatment-resistant epilepsy..."http://www.ncbi.nlm.nih.gov/pubmed/24237632
2014: "Cannabinoids for epilepsy...Marijuana appears to have anti-epileptic effects..." http://www.ncbi.nlm.nih.gov/pubmed/24595491
"Cannabidiol (CBD) is a non-psychoactive, well-tolerated, anticonvulsant plant cannabinoid..." http://www.ncbi.nlm.nih.gov/pubmed/24642454
"The case for medical marijuana in epilepsy"
"Pure CBD appears to be an ideal candidate among phytocannabinoids as a therapy for treatment-resistant epilepsy."http://www.ncbi.nlm.nih.gov/pubmed/24854434
"...the desire to isolate and treat with pharmaceutical grade compounds from cannabis (specifically CBD) may be inferior to therapy with whole plant extracts.” http://www.ncbi.nlm.nih.gov/pubmed/24854149
“Cannabis has been used to treat disease since ancient times. Δ9 -Tetrahydrocannabinol (Δ9 -THC) is the major psychoactive ingredient and CBD is the major nonpsychoactive ingredient in cannabis. Cannabis and Δ9 -THC are anticonvulsant... CBD is anticonvulsant... CBD has neuroprotective and antiinflammatory effects, and it appears to be well tolerated in humans...More recent anecdotal reports of high-ratio CBD:Δ9 -THC medical marijuana have claimed efficacy,”http://www.ncbi.nlm.nih.gov/pubmed/24854329
(links compiled by David Worell)
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