Sunday, 15 June 2014

What does Sativex do for Cancer? Could it improve all terminally ill patients? Study research

Sativex is the European trade name for a chemical compound called Nabiximol, a pharmaceutical product created only for prescription-based use by GW Pharmaceuticals.
Nabiximol is a chemical compound delivered by oral spray and is often recommended for multiple sclerosis and to control neuropathic pain and spasticity. According to Wikipedia, “The drug is a pharmaceutical product standardised in composition, formulation, and dose, although it is still effectively a tincture of the cannabis plant.” It is a tincture lacking the full spectrum of 60+ cannabinoids found in the cannabis plant, having been refined to contain only a few.
Marijuana is a plant that grows in the ground. If you take the flowers of that plant, dry them out and add nothing to them, you have smokable marijuana. If you take the green, growing leaves, stems and immature flowering buds and run them through a juicer you have raw cannabis juice. The stalk can be used for animal food or ground into high-quality fiber stock.
You can steep the flowers in alcohol, agave or glycerin and create a tincture.  Through heating, chemicals from the flowers transfer into the liquid medium which is then cooled and sipped- or, in the case of Sativex, sprayed. Cannabis tincture is considered to be a medical marijuana product.
Tinctures like Sativex contain the essential components of marijuana and therefore are legally considered to be marijuana.  Yet, it's legal with a prescription.  
Cannabis is NOT a drug it is however a medicinal herb. just like valariana officianialis , dandelion root, echinechia, or any other medicinal herb you can get at your local herbal shop. Cannabis should be properly labeled as such and sold in herbal shops , not taxed to death when it does become legal or labeled medicinal.
However if your a Cancer sufferer and Cannabis Oil with the THC and CBD can not be found.  Then is this a product the Medicial Hospital treatment for cancer for the Terminal Ill should look at the Cannaloids, the structure of the medicine could it help in any way? 
GW Pharmaceuticals, the manufacturer of Sativex;
"Sativex® contains active ingredients called ‘cannabinoids’, which are 
extracted from cannabis plants grown and processed under strictly 
controlled conditions. It is composed primarily of a 1:1 ratio of two 
cannabinoids-CBD (cannabidiol-a non-psychoactive cannabinoid) and THC 
(delta-9-tetrahydrocannabinol)"
The possibility that cannabinoids, including endocannabinoids, may treat cancer is supported by an ever increasing body of available evidence. In simple terms, cancer occurs because cells become immortalised; they fail to heed customary signals to turn off growth. A normal function of remodelling in the body requires that cells die on cue. This is called apoptosis, or programmed cell death and this process fails to proceed normally after malignant transformation. As will be discussed in greater detail below, THC, CBD, and perhaps other phytocannabinoids promote the re-emergence of apoptosis so that certain cancer cell types will in fact heed the signals, stop dividing, and die. The process of apoptosis is judged by observation of several phenomena: reduced cellular volume, condensation of nuclear chromatin, changes in distribution of phospholipids in plasma membranes, and cleavage of chromatin into DNA fragments called NDA ladders.
Sativex is an WHOLE PLANT extract. It contains all the cannabinoids, flavonoids and terpenes present in the plants from which it is made. It is pharmacologically identical to cannabis.
"There is no evidence to suggest that Sativex® produces a ‘high’ comparable to recreational cannabis.
One of the cannabinoids in Sativex is THC whereas the other principal
cannabinoid is CBD, a non-psychoactive molecule. Evidence suggests that
CBD may modulate many of the unwanted effects of THC. Hence, through the
incorporation of CBD and the utilization of an oromucosal spray
delivery system which is administered through careful self-titration
(dose adjustment) and which keeps THC from entering the blood too
rapidly, patients are able to obtain symptom relief without experiencing
a 'high'."

However to fight cancer the two ingredients is the THC and CBD oil which I have noted within my blog else where.
Two cannabinoids, not the whole plants worth. Among the missing; Cannabigerols (CBG), Cannabichromenes (CBC), Cannabinol (CBN) and cannabinodiol (CBDL), other cannabinoids (such as cannabicyclol (CBL), cannabielsoin (CBE), cannabitriol (CBT) and other miscellaneous types).
Another method by which tumours grow is by ensuring that they are nourished: they send out signals to promote angiogenesis, the growth of new blood vessels. Cannabinoids may turn off these signals as well. Finally, cannabinoids may display complex interactions with oncogenes. Pre-clinical studies have highlighted an anti-cancer role for phytocannabinoids via CB receptor and non-CB receptor mediated pathways in a broad spectrum of cancer types bothin vitroandin vivo
Within a mouse model of breast cancer, it has been reported that the cannabinoid Cannabidiol (CBD) is able to down regulate the presence of a protein that is elevated in tumoursiand these results have subsequently been replicated in human cancers.  
Cannabinoid receptors (both CB1 and CB2) are present in significantly higher concentrations in many human prostate cancer cell lines.  
http://www.gwpharm.com/oncology.aspx
The cannabinoid-based medicine Sativex is BDS presented as oromucosal spray that results from the combination of THC-BDS and CBD-BDS at a 1:1 (w/w) ratio and to which excipients are subsequently added.
THC but not CBD has been shown to engage cannabinoid receptors to promote tumor cell death.  Now when the patient doesn't have pain, we have to look at the active ingredient.  

Copyright owner Jennifer Weatherstone for the following:  16 June 2014 THC triggers the accumulation of de novo–synthesized ceramide, which leads in turn to stimulation of autophagy and apoptosis.  This would lead me to believe, as I will allege if the mixture was 2:1:1 being the THC is 2 parts it will counteract the high and be more effective on the cell death.  http://mct.aacrjournals.org/content/10/1/90.full
We have a medicine now allowed in many countries for cancer.  However they are just looking at the high for pain yet in fact the THC has been noted by Rick Simpson's oil to be the part to fight cancer cells.  
http://www.medicalcannabis.com/indications-for-use/cancer/
Benefits of Cannabis.  http://www.pinterest.com/pin/508203139174239717/  Relating to the THC and CBD.  

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